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CEFOXITIN SODIUM | ||
PRODUCT IDENTIFICATION |
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CAS NO. | 35607-66-0
(Base) 33564-30-6 (Sodium) |
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EINECS NO. | 252-641-2, 251-574-6 | |
FORMULA | C16H17N3O7S2·Na | |
MOL WT. | 449.44 | |
H.S. CODE |
2941.90 | |
TOXICITY |
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SYNONYMS | Cefoxitina de sodio; Cefoxitin monosodium salt; | |
Monosodium (6R,7R)-3-carbamoyloxymethyl-7-methoxy-8-oxo-7-[2-(2-thienyl) acetamido]- 5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; | ||
PRICE | ||
CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE | White to off-white crystalline powder | |
MELTING POINT | ||
BOILING POINT | ||
SPECIFIC GRAVITY | ||
SOLUBILITY IN WATER | ||
pH | ||
VAPOR DENSITY |
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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FLASH POINT |
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STABILITY | Stable under ordinary conditions. | |
GENERAL DESCRIPTION & APPLICATIONS |
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Cefoxitin Sodium: a broad range of gram-positive and gram-negative
second generation cephalosporins with resistance to beta-lactamase; administered
intramuscularly or intravenously. Chemical designation is Monosodium
(6R-cis)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-(2-thienylacetamido)-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylate.
Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. |
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SALES SPECIFICATION | ||
APPEARANCE |
White to off-white crystalline powder | |
IDENTIFICATION |
Complies Test A,B |
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ASSAY |
865 ug/mg min | |
MOISTURE | 2.5% max | |
pH |
4.0 - 6.0 | |
IMPURITY |
0.5% max (individual), 2.0% max (sum) |
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TRANSPORTATION | ||
PACKING | 5kgs - 20kgs | |
HAZARD CLASS | ||
UN NO. | ||
OTHER INFORMATION | ||
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